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2 edition of Tracheal organ culture as air pollution damage indicator found in the catalog.

Tracheal organ culture as air pollution damage indicator

Leonard J Schiff


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Tracheal organ culture as air pollution damage indicator by Leonard J Schiff Download PDF EPUB FB2

V-/EPA United States Environmental Protection Agency Health Effects Research Laborarory Research Triangle Park NC Research and Development EPA/S May Project Summary Tracheal Organ Culture as Air Pollution Damage Indicator Leonard J. Schiff This report presents the results of a study conducted to determine the effects of various energy-related ef- fluents on.

Get this from a library. Tracheal organ culture as air pollution damage indicator. [Leonard J Schiff; Health Effects Research Laboratory (Research Triangle Park, N.C.)]. Air pollution may be damaging every organ and virtually every cell in the human body, according to a comprehensive new global review.

The research shows. Air pollution has been shown to minimally impact not just the lungs, but the heart, brain, and reproductive system. “When something comes in [to the body] that's potentially toxic, it's. Objectives: We aimed to develop an air interface EVOC using pig tracheas in the study of influenza infection demonstrating that tracheal explants can be effectively maintained in organ culture and support productive influenza infection.

Methods: Tracheal explants were maintained in the air interface EVOC system for 7 by: Exposure of hamster tracheal rings in organ culture to virulent Mycoplasma pneumoniae organisms leads to alterations in macromolecular biosynthesis and metabolic activity of the respiratory epithelial cells.

Avirulent organisms derived from the same parent strain do not produce these effects. During the course of infection by virulent mycoplasmas, tracheal rings show an initial increase in.

Air Pollution Effects on General Health. Clean air is a basic precondition of our health. However, most of us living in United States and other developed countries suffer from exposure to many air pollutants that put our health at risk. Air pollution effects greatly human health, mainly the respiratory and cardiovascular system.

Hamster tracheal organ cultures were inoculated with virulent Mycoplasma pneumoniae colony forming units/ml. At daily intervals a specimen was examined for ciliary motion and then removed and processed for immunofluorescent study. After 48 hours ciliary motion had slowed and bright-staining granular material was seen along the luminal surface of the epithelium.

Growth of Bordetella pertussis was obtained in organ culture of chick trachea, but not in serum-free medium even when an emulsion of trachea was added.

The necessary "milieu intimately related to the physiological architecture and function of the tracheal fragments" in the organ culture is unknown. It was not, however, organ-specific: similar growth was obtained in organ culture of chick-embryo. Avian Metapneumovirus (aMPV) primarily infects cells of the upper respiratory tract.

Not much is known about the virus-host interaction, which may significantly influence the outcome of infection and the development of clinical disease. Tracheal organ cultures (TOC) allow the close investigation of virus-host interaction with primary cells.

In addition passages in TOC and the identification of. Tracheal Organ Culture The method used to prepare the bovine fetal tracheal (BFT) organ cultures was modified from that described oviduct ciliated epithelium was assessed using an in vitro tracheal organ culture (TOC) and oviduct organ culture (OOC) system.

Trachea, in vertebrates and invertebrates, a tube or system of tubes that carries insects, a few land arachnids, and myriapods, the trachea is an elaborate system of small, branching tubes that carry oxygen to individual body cells; in most land vertebrates, the trachea is the windpipe, which conveys air from the larynx to the two main bronchi, with the lungs and their air sacs as the.

When culture medium was added on top of the air- way epithelial cell surface, the damage caused by ozone was reduced. The viability was 45% of control values when ml of culture fluid was added, and it was the same as in the control vessel when ml was added.

a tracheal organ culture system, that expos ure to ci garette smoke dir ectly increases the uptake of asbestos bers by tracheal epithelial cells, and that this process is mediated by.

Air pollution particles activate NF-κB on contact with airway epithelial cell surfaces. and also oxidatively damage DNA in vitro.

There is a consensus that, × amino acids, and 10% chicken serum, and maintained in air plus 5% CO 2 organ culture in an incubator at 37 °C for 1 additional hour (referred to as a 2-h dust exposure). The. A new report contains a long list of health problems caused by air pollution including Heart and Lung Desease, diabetes, dementia and bladder cancer.

The review in the medical journal Chest goes on to claim that the damage caused by pollutants such as these may be harming every organ and virtually every cell in the human body. Human respiratory system - Human respiratory system - The trachea and the stem bronchi: Below the larynx lies the trachea, a tube about 10 to 12 cm ( to inches) long and 2 cm ( inch) wide.

Its wall is stiffened by 16 to 20 characteristic horseshoe-shaped, incomplete cartilage rings that open toward the back and are embedded in a dense connective tissue. Sputum and Tracheal Aspirate specimens are subject to screening for specimen acceptibility, including those from Transplant patients.

Unacceptable specimens are rejected for culture, and the results of the unacceptable screening smears are called to the ordering physician, or to the patient's nurse. Sturgess J and Reid L () The organ culture study of the effects of drugs on the secretory activity of the human bronchial submucosal gland.

Clin Sci Takano H, Yoshikawa T, Ichinose T et al. () Diesel exhaust particles enhance antigen-induced airway inflammation and local cytokine expression in mice. Air pollution poses a great environmental risk to health. Outdoor fine particulate matter (particulate matter with an aerodynamic diameter million disability-adjusted life years lost according to the Global Burden of Disease Report.

The need to raise awareness of the health impacts of air pollution. Despite the well-documented negative effects of air pollution on health, 1 there appears to be a lack of public understanding and awareness in this area.

2 There is a need for greater understanding of the long-term effects of poor air quality and of the positive action people can take to reduce their exposure to air pollution.organ cultures and the physiological differences with other non-tracheal cultures make it difficult to study critical events occurring during early infection.

Primary cell culture systems provide a valuable intermediate between animal studies and the use of cell lines to study mechanisms of infection and the immediate host re.Although air pollution is well known to be harmful to the lung and airways, it can also damage most other organ systems of the body.

It is estimated that aboutlung cancer deaths and million COPD deaths can be attributed to air pollution, but air pollution may also ac-count for 19% of all cardiovascular deaths and 21% of all stroke.